The cardiovascular safety of rosiglitazone

@article{Ajjan2008TheCS,
  title={The cardiovascular safety of rosiglitazone},
  author={Ramzi A. Ajjan and Peter J Grant},
  journal={Expert Opinion on Drug Safety},
  year={2008},
  volume={7},
  pages={367 - 376}
}
Background: Thiazolidinediones (rosiglitazone, pioglitazone) influence insulin sensitivity and are used for the treatment of Type 2 diabetes. Rosiglitazone achieves sustained improvements in glycaemic control, whilst having pleiotropic effects on cardiovascular risk factors. However, analysis of cardiovascular outcomes has been controversial. Objectives: Review the cardiovascular safety of rosiglitazone by conducting a literature search. Methods: We conducted a PubMed search and critically… 
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References

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TLDR
Patients and providers should consider the potential for serious adverse cardiovascular effects of treatment with rosiglitazone for type 2 diabetes mellitus as well as the availability of outcome data for myocardial infarction and death from cardiovascular causes.
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TLDR
The RECORD study should provide robust data on the extent to which rosiglitazone, in combination with metformin or sulphonylurea therapy, affects CV outcomes and progression of diabetes in the long term.
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TLDR
Among patients with impaired glucose tolerance or type 2 diabetes, rosiglitazone use for at least 12 months is associated with a significantly increased risk of myocardial infarction and heart failure, without a significantlyIncreased risk of cardiovascular mortality.
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TLDR
A meta-analysis of 42 clinical trials involving 27847 patients concluded that treatment with rosiglitazone, a widely prescribed, peroxisome proliferator-activated receptor- agonist, was associated with an approximately 43% greater risk for myocardial infarction and an approximately 64% greaterrisk for cardiovascular death than placebo or other antidiabetic regimens.
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TLDR
The interim findings from this ongoing study were inconclusive regarding the effect of rosiglitazone on the overall risk of hospitalization or death from cardiovascular causes.
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TLDR
Thiazolidinediones have similar effects on glycemic control and body weight and head-to-head comparative trials as well as longer-term cardiovascular outcome studies are needed to determine whether there are differences in efficacy between the 2 thiazolidinees.
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TLDR
Analysis of double-blind, placebo-controlled studies with RSG and PIO in patients with type 2 diabetes found that subjects treated with PIO were more obese and showed more pronounced hyperglycemia and dyslipidemia, while studies conducted with P IO showed more beneficial effects on blood lipids.
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TLDR
Investigation of the cardiac safety and antihyperglycemic effect of rosiglitazone in patients with type 2 diabetes found decreases in ambulatory diastolic blood pressure with RSG were superior to those with GLB.
Rapid Effects of Rosiglitazone Treatment on Endothelial Function and Inflammatory Biomarkers
TLDR
A direct effect of TZD treatment on endothelial function and inflammatory biomarkers of arteriosclerosis is suggested, promoting the concept that TZDs, independent of their metabolic action, may exhibit protective effects in the vessel wall.
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