The cardiovascular response of normal humans to the administration of endotoxin.

@article{Suffredini1989TheCR,
  title={The cardiovascular response of normal humans to the administration of endotoxin.},
  author={Anthony F. Suffredini and Robert E. Fromm and Margaret M. Parker and Mathew Brenner and Joseph A Kovacs and Robert A. Wesley and Joseph E. Parrillo},
  journal={The New England journal of medicine},
  year={1989},
  volume={321 5},
  pages={280-7}
}
Marked abnormalities in cardiovascular function accompany septic shock, and bacterial endotoxin is believed to be one of the principal mediators of these abnormalities. To evaluate the cardiovascular effects of endotoxemia in humans, we measured hemodynamic variables in nine normal subjects given an intravenous bolus dose of endotoxin (Escherichia coli, 4 ng per kilogram of body weight) and in six normal subjects given a bolus dose of saline, before and three hours after administration. All the… CONTINUE READING