The cardiovascular effects and implications of peroxynitrite.

  title={The cardiovascular effects and implications of peroxynitrite.},
  author={Russell S Ronson and Masafumi Nakamura and Jakob Vinten-Johansen},
  journal={Cardiovascular research},
  volume={44 1},
Nitric oxide is an endogenous autacoid produced primarily by the vascular endothelium. Under basal conditions, nitric oxide undergoes a rapid biradical reaction with superoxide anions to form peroxynitrite. This reaction, and hence the formation of peroxynitrite is augmented in inflammatory-like conditions such as ischemia-reperfusion injury when both substrates are present in high concentrations. Peroxynitrite has been implicated as a physiologically active toxic metabolite of nitric oxide… CONTINUE READING