The cardioprotective protein apolipoprotein A1 promotes potent anti-tumorigenic effects.

Abstract

Here, we show that apolipoprotein A1 (apoA1), the major protein component of high density lipoprotein (HDL), through both innate and adaptive immune processes, potently suppresses tumor growth and metastasis in multiple animal tumor models, including the aggressive B16F10L murine malignant melanoma model. Mice expressing the human apoA1 transgene (A1Tg… (More)
DOI: 10.1074/jbc.M113.468967

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