The cardioprotective effects of icariin on the isoprenaline-induced takotsubo-like rat model: Involvement of reactive oxygen species and the TLR4/NF-κB signaling pathway.

@article{Qi2019TheCE,
  title={The cardioprotective effects of icariin on the isoprenaline-induced takotsubo-like rat model: Involvement of reactive oxygen species and the TLR4/NF-$\kappa$B signaling pathway.},
  author={Chunlei Qi and Yangzhen Shao and Xuesong Liu and Daxin Wang and Xueping Li},
  journal={International immunopharmacology},
  year={2019},
  volume={74},
  pages={
          105733
        }
}

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TLDR
The results suggest that Ica might have beneficial cardioprotective effects in attenuating cardiotoxicity in patients requiring anthracycline chemotherapy through the inhibition of oxidative stress and, in particular, through the modulation of Cav-1 expression levels and the involvement of PDE5a activity, thereby leading to cardiac cell survival.

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The pathophysiological mechanisms related to Takotsubo syndrome; preclinical TTS models and platforms such as animal models, human-induced pluripotent stem cell-derived cardiomyocyte models and their usefulness for TTS studies are reviewed, including exploring and improving the understanding of the pathomechanism of the disease.

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Research progress on icariin, a traditional Chinese medicine extract, in the treatment of asthma.

TLDR
Icariin is considered a novel therapy in controlling asthma; however, the mechanism is still worth further investigation.

Protein tyrosine phosphatase receptor-type O expression as a prognostic marker in patients with acute coronary syndrome undergoing percutaneous coronary intervention: A prospective study

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PTPRO expression in peripheral blood mononuclear cells after PCI is associated with the prognosis of patients with ACS, with high PTPRO expression indicating a high risk of poor prognosis in patients with ACS.

Hepatic stellate cells specific liposomes with the Toll‐like receptor 4 shRNA attenuates liver fibrosis

TLDR
The outcome of this study revealed that the VitA‐coupled cationic liposomes delivered the TLR4 shRNA to aHSCs more efficiently, as compared to the uncoupledCationic Liposomes, both in the in vitro and in vivo conditions.

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