The cardioprotective effects of L-carnitine on rat cardiac injury, apoptosis, and oxidative stress caused by amethopterin

@article{Tousson2016TheCE,
  title={The cardioprotective effects of L-carnitine on rat cardiac injury, apoptosis, and oxidative stress caused by amethopterin},
  author={Ehab Tousson and Ezar H. Hafez and Somia Zaki and Amani Gad},
  journal={Environmental Science and Pollution Research},
  year={2016},
  volume={23},
  pages={20600-20608}
}
Amethopterin is used as a chemotherapeutic agent, and its antioxidant activity is used to treat many cancer types. This study aimed to study the ameliorating effect of L-carnitine against amethopterin-induced cardiac injury and oxidative stress in male rats. Sixty male albino rats were equally divided into six groups; the first and second groups were the control and L-carnitine groups, respectively, while the third group was treated with amethopterin rat group; the fourth and fifth groups were… Expand
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Treatment (Co- and post-) with L-carnitine were improved the biochemical, histopathological and immunohistochemical alterations in large intestine that treated with Amethopterin. Expand
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The results suggest that L-Car, possibly via its free radical scavenging and antioxidant properties, ameliorates MTX-induced oxidative organ injury and inhibits leukocyte apoptosis and may be promising in alleviating the systemic side-effects of chemotherapeutics. Expand
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Methotrexate (MTX) is used as a chemotherapeutic agent used to treat many cancer types. The present study aimed to examine the possible modifying effects of l-carnitine against hepatic and renalExpand
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The findings of the present study suggest that beta-glucan, through its antioxidant and immunoregulatory effects, may be of therapeutic value in alleviating the leukocyte apoptosis, oxidative tissue injury and thereby the intestinal and hepatorenal side effects of methotrexate treatment. Expand
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