The cardiomyocyte molecular clock regulates the circadian expression of Kcnh2 and contributes to ventricular repolarization.

@article{Schroder2015TheCM,
  title={The cardiomyocyte molecular clock regulates the circadian expression of Kcnh2 and contributes to ventricular repolarization.},
  author={Elizabeth A. Schroder and Don E. Burgess and Xiping Zhang and Mellani Lefta and Jennifer Lawson Smith and Abhijit R. Patwardhan and Daniel C Bartos and Claude S Elayi and Karyn A Esser and Brian P. Delisle},
  journal={Heart rhythm},
  year={2015},
  volume={12 6},
  pages={1306-14}
}
BACKGROUND Sudden cardiac death (SCD) follows a diurnal variation. Data suggest the timing of SCD is influenced by circadian (~24-hour) changes in neurohumoral and cardiomyocyte-specific regulation of the heart's electrical properties. The basic helix-loop-helix transcription factors brain muscle arnt-like1 (BMAL1) and circadian locomotor output control kaput (CLOCK) coordinate the circadian expression of select genes. OBJECTIVE We sought to test whether Bmal1 expression in cardiomyocytes… CONTINUE READING
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