The cardiac sarcoplasmic/endoplasmic reticulum calcium ATPase: a potent target for cardiovascular diseases

@article{Kawase2008TheCS,
  title={The cardiac sarcoplasmic/endoplasmic reticulum calcium ATPase: a potent target for cardiovascular diseases},
  author={Yoshiaki Kawase and Roger J. Hajjar},
  journal={Nature Clinical Practice Cardiovascular Medicine},
  year={2008},
  volume={5},
  pages={554-565}
}
The cardiac isoform of the sarcoplasmic/endoplasmic reticulum calcium ATPase (SERCA2a) is a calcium ion (Ca2+) pump powered by ATP hydrolysis. SERCA2a transfers Ca2+ from the cytosol of the cardiomyocyte to the lumen of the sarcoplasmic reticulum during muscle relaxation. As such, this transporter has a key role in cardiomyocyte Ca2+ regulation. In both experimental models and human heart failure, SERCA2a expression is significantly decreased, which leads to abnormal Ca2+ handling and a… CONTINUE READING

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