The cardiac renin-angiotensin system in heart failure.

  title={The cardiac renin-angiotensin system in heart failure.},
  author={C. I. Johnston and Bruno Fabris and Katsuya Yoshida},
  journal={American heart journal},
  volume={126 3 Pt 2},
The success of angiotensin-converting enzyme (ACE) inhibitors in reducing cardiovascular morbidity and mortality rates has led to a reexamination of the role of the renin-angiotensin system in pathophysiology. Ventricular dysfunction leading to congestive cardiac failure is associated with sequential activation of the sympathetic system and increases in plasma atrial natriuretic peptide; however, increases in plasma renin and aldosterone do not occur until very late. The renin-angiotensin… CONTINUE READING


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