The cardiac phenotype induced by PPARalpha overexpression mimics that caused by diabetes mellitus.

@article{Finck2002TheCP,
  title={The cardiac phenotype induced by PPARalpha overexpression mimics that caused by diabetes mellitus.},
  author={Brian N. Finck and John J. Lehman and Teresa C. Leone and Michael J. Welch and Michael J Bennett and Attila Kov{\'a}cs and Xianlin Han and Richard W. Gross and Ray Kozak and Gary D. Lopaschuk and Daniel P. Kelly},
  journal={The Journal of clinical investigation},
  year={2002},
  volume={109 1},
  pages={
          121-30
        }
}
Recent evidence has defined an important role for PPARalpha in the transcriptional control of cardiac energy metabolism. To investigate the role of PPARalpha in the genesis of the metabolic and functional derangements of diabetic cardiomyopathy, mice with cardiac-restricted overexpression of PPARalpha (MHC-PPAR) were produced and characterized. The expression of PPARalpha target genes involved in cardiac fatty acid uptake and oxidation pathways was increased in MHC-PPAR mice. Surprisingly, the… 

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