The cardiac phenotype induced by PPARalpha overexpression mimics that caused by diabetes mellitus.

@article{Finck2002TheCP,
  title={The cardiac phenotype induced by PPARalpha overexpression mimics that caused by diabetes mellitus.},
  author={B. Finck and J. J. Lehman and T. Leone and M. Welch and M. Bennett and A. Kov{\'a}cs and Xianlin Han and R. Gross and R. Kozak and G. Lopaschuk and D. Kelly},
  journal={The Journal of clinical investigation},
  year={2002},
  volume={109 1},
  pages={
          121-30
        }
}
Recent evidence has defined an important role for PPARalpha in the transcriptional control of cardiac energy metabolism. To investigate the role of PPARalpha in the genesis of the metabolic and functional derangements of diabetic cardiomyopathy, mice with cardiac-restricted overexpression of PPARalpha (MHC-PPAR) were produced and characterized. The expression of PPARalpha target genes involved in cardiac fatty acid uptake and oxidation pathways was increased in MHC-PPAR mice. Surprisingly, the… Expand
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  • B. Finck, Xianlin Han, +5 authors D. Kelly
  • Biology, Medicine
  • Proceedings of the National Academy of Sciences of the United States of America
  • 2003
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References

SHOWING 1-10 OF 52 REFERENCES
PPAR signaling in the control of cardiac energy metabolism.
A gender-related defect in lipid metabolism and glucose homeostasis in peroxisome proliferator- activated receptor alpha- deficient mice.
A critical role for the peroxisome proliferator-activated receptor alpha (PPARalpha) in the cellular fasting response: the PPARalpha-null mouse as a model of fatty acid oxidation disorders.
A novel mouse model of lipotoxic cardiomyopathy.
Streptozotocin-induced changes in cardiac gene expression in the absence of severe contractile dysfunction.
Regulation of energy substrate metabolism in the diabetic heart.
Myocardial substrate metabolism: implications for diabetic cardiomyopathy.
...
1
2
3
4
5
...