The cardiac glycoside oleandrin induces apoptosis in human colon cancer cells via the mitochondrial pathway

@article{Pan2017TheCG,
  title={The cardiac glycoside oleandrin induces apoptosis in human colon cancer cells via the mitochondrial pathway},
  author={Li Pan and Yuming Zhang and Wanlu Zhao and Xia Zhou and Chunxia Wang and Fan Deng},
  journal={Cancer Chemotherapy and Pharmacology},
  year={2017},
  volume={80},
  pages={91-100}
}
Evidence indicates that the cardiac glycoside oleandrin exhibits cytotoxic activity against several different types of cancer. However, the specific mechanisms underlying oleandrin-induced anti-tumor effects remain largely unknown. The present study examined the anti-cancer effect and underlying mechanism of oleandrin on human colon cancer cells. The cytotoxicity and IC50 of five small molecule compounds (oleandrin, neriifolin, strophanthidin, gitoxigenin, and convallatoxin) in human colon… CONTINUE READING