The cardiac cycle: regulation and energy oscillations.

  title={The cardiac cycle: regulation and energy oscillations.},
  author={Joan Wikman-Coffelt and R. Sievers and Robert J. Coffelt and William W. Parmley},
  journal={The American journal of physiology},
  volume={245 2},
Cyclical changes in energy-related metabolites were observed in glucose-perfused but not pyruvate-perfused isolated working rat hearts. A chronological study of various phases of the cardiac cycle indicated maximum changes in metabolites occurred at half time to peak pressure (dF/dtmax). The high-energy phosphates ATP and phosphocreatine, as well as the glycolytic metabolites, glucose 6-phosphate and pyruvate, reached minimum values immediately prior to peak systole and maximum values during… CONTINUE READING
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