The carcinogenicity of smegma: debunking a myth

@article{VanHowe2006TheCO,
  title={The carcinogenicity of smegma: debunking a myth},
  author={RS Van Howe and FM Hodges},
  journal={Journal of the European Academy of Dermatology and Venereology},
  year={2006},
  volume={20}
}
  • RS Van Howe, FM Hodges
  • Published 1 October 2006
  • Medicine
  • Journal of the European Academy of Dermatology and Venereology
Background  Smegma is widely believed to cause penile, cervical and prostate cancer. This nearly ubiquitous myth continues to permeate the medical literature despite a lack of valid supportive evidence. 
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Re: ‘RS Van Howe, FM Hodges. The carcinogenicity of smegma: debunking a myth.’ An example of myth and mythchief making?
  • J. Waskett, B. Morris
  • Medicine
    Journal of the European Academy of Dermatology and Venereology : JEADV
  • 2008
Editor This ‘Review’ and re-analysis of published data misrepresents sources, is statistically dubious, has fallacious reasoning, is inconsistent and contains biased statements that make it fatally
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References

SHOWING 1-10 OF 80 REFERENCES
Preputial ectopic sebaceous glands mimicking molluscum contagiosum.
TLDR
Investigation revealed the presence of a sebaceous gland opening directly onto the surface and hyperplasia of the epithelium in a 12-year-old boy with a peculiar presentation of preputial papular lesions similar to molluscum contagiosum.
Carcinoma of the Glans penis Arising 20 Years after Lichen sclerosus
TLDR
A case of LS of the glans penis which occurred in 1976 is described and within the next 20 years, the patient developed carcinoma at this site.
Squamous cell carcinoma of the penis arising on lichen sclerosus et atrophicus
TLDR
A case is described in a 63‐year‐old man who had been diagnosed of lichen sclerosus et atrophicus 3 years before, and the possible pathogenesis is discussed.
Plasma cell balanitis and vulvitis (of Zoon). A study of 10 cases.
TLDR
Topical and intralesional corticosteroid preparations resulted in satisfactory improvements in all cases, male and female, and two males subsequently underwent circumcision, which was curative.
Bowen's disease of the glans penis (erythroplasia of Queyrat) in plasma cell balanitis.
TLDR
Radiotherapy was performed with good clinical response and subsequent histopathologic proof of complete remission of the lesion, and it is assumed that carcinoma in situ may have arisen due to the chronic inflammation of Zoon's balanitis plasmacellularis.
Squamous cell carcinoma of the penis in a circumcised man: a case for dermatology and urology, and review of the literature.
TLDR
A patient is presented, circumcised at birth, who showed penile squamous cell carcinoma in situ and was treated with carbon dioxide laser ablation, and probably early invasive penile carcinoma.
Penile cancer among patients with genital lichen sclerosus.
Tyson's "glands." Ectopic sebaceous glands and papillomatosis penis.
TLDR
It is suggested that the term Tyson's glands be replaced by the appropriate descriptive expressions: papillomatosis corona penis or ectopic sebaceous glands.
Role of Viral Agents in the Pathogenesis of Kaposi’s Sarcoma
TLDR
The detection of human herpesvirus 8 (HHV-8) in all the epidemiological and histological forms of KS makes it the most attractive candidate causative agent to date.
Cervical cytology screening in Calcutta and adjoining areas with special reference to carcinoma of the uterine cervix.
TLDR
A total of 1232 female subjects including 100 prostitutes from Calcutta and adjoining areas in the age group of 21-70 years were screened for cervical pathology according to the method of Papanicolaou, which failed to support the smegma theory of cervical carcinoma.
...
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