The carcinogenic potential of ethyl carbamate (urethane): risk assessment at human dietary exposure levels.

@article{Schlatter1990TheCP,
  title={The carcinogenic potential of ethyl carbamate (urethane): risk assessment at human dietary exposure levels.},
  author={Josef Schlatter and Werner K. Lutz},
  journal={Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association},
  year={1990},
  volume={28 3},
  pages={
          205-11
        }
}
Ethyl carbamate is found in fermented foods: bread contains 3-15 ng/g, stone-fruit brandies 200-20,000 ng/g, and about one-third of table-wine samples analysed contained more than 10 ng/g. In animals, ethyl carbamate is degraded to CO2, H2O and NH3, with intermediate formation of ethanol. This degradation has been shown to be inhibited (postponed) in the mouse by ethanol concentrations in the blood of about 0.15% and higher. A quantitatively minor pathway involves a two-step oxidation of the… CONTINUE READING

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