The carcinogenic potency of carbon particles with and without PAH after repeated intratracheal administration in the rat.

@article{Dasenbrock1996TheCP,
  title={The carcinogenic potency of carbon particles with and without PAH after repeated intratracheal administration in the rat.},
  author={Clemens Dasenbrock and Lawrence H. Peters and Otto H Creutzenberg and Uwe Heinrich},
  journal={Toxicology letters},
  year={1996},
  volume={88 1-3},
  pages={
          15-21
        }
}
The role of carcinogenic PAH in soot- and carbon black-related lung tumour induction in rats was investigated after intratracheal administration of carbon blacks (CB) and two types of diesel soot (DS), either as original or as toluene extracted particles. The total particle dose per animal was 15 mg subdivided into 16-17 weekly applications. There was one vehicle control and two groups were treated with a total dose of either 30 or 15 mg pure BaP as positive control. The main tumour results… CONTINUE READING
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