The carcinogen 1-methylpyrene forms benzylic DNA adducts in mouse and rat tissues in vivo via a reactive sulphuric acid ester

@article{Bendadani2013TheC1,
  title={The carcinogen 1-methylpyrene forms benzylic DNA adducts in mouse and rat tissues in vivo via a reactive sulphuric acid ester},
  author={Carolin Bendadani and Walter Meinl and Bernhard Hans Monien and Gisela Dobbernack and Hansruedi Glatt},
  journal={Archives of Toxicology},
  year={2013},
  volume={88},
  pages={815-821}
}
The common polycyclic aromatic hydrocarbon 1-methylpyrene is hepatocarcinogenic in the newborn mouse assay. In vitro studies showed that it is metabolically activated via benzylic hydroxylation and sulphation to a reactive ester, which forms benzylic DNA adducts, N 2-(1-methylpyrenyl)-2′-deoxyguanosine (MPdG) and N 6-(1-methylpyrenyl)-2′-deoxyadenosine (MPdA). Formation of these adducts was also observed in animals treated with the metabolites, 1-hydroxymethylpyrene and 1-sulphooxymethylpyrene… CONTINUE READING

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