The carcinoembryonic antigen gene family: structure, expression and evolution.

  title={The carcinoembryonic antigen gene family: structure, expression and evolution.},
  author={John A. Thompson and Wolfgang Zimmermann},
  journal={Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine},
  volume={9 2-3},
The molecular cloning of carcinoembryonic antigen (CEA) and several cross-reacting antigens reveals a basic domain structure for the whole family, which shows structural similarities to the immunoglobulin superfamily. The CEA family consists of approximately 10 genes which are localized in two clusters on chromosome 19. So far, mRNA species for five of these genes have been identified which show tissue variability in their transcriptional activity. Expression of some of these genes in… CONTINUE READING

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