The carboxyl terminus of the cystic fibrosis transmembrane conductance regulator binds to AP-2 clathrin adaptors.

@article{Weixel2000TheCT,
  title={The carboxyl terminus of the cystic fibrosis transmembrane conductance regulator binds to AP-2 clathrin adaptors.},
  author={Kelly M. Weixel and Neil A. Bradbury},
  journal={The Journal of biological chemistry},
  year={2000},
  volume={275 5},
  pages={3655-60}
}
The cystic fibrosis transmembrane conductance regulator (CFTR) undergoes rapid and efficient endocytosis. Since functionally active CFTR is found in purified clathrin-coated vesicles isolated from both cultured epithelial cells and intact epithelial tissues, we investigated the molecular mechanisms whereby CFTR could enter such endocytic clathrin-coated… CONTINUE READING