The carboxyl terminus of mouse delta-opioid receptor is not required for agonist-dependent activation.

@article{Zhu1997TheCT,
  title={The carboxyl terminus of mouse delta-opioid receptor is not required for agonist-dependent activation.},
  author={Xianyou Zhu and Canding Wang and Z. Cheng and Yanfeng Wu and Donghui Zhou and G. Pei},
  journal={Biochemical and biophysical research communications},
  year={1997},
  volume={232 2},
  pages={
          513-6
        }
}
The pharmacological effects caused by use of opiate are exerted through the opioid receptors (ORs). ORs couple to the inhibitory G protein (Gi) and result in decreased cAMP levels upon activation by specific agonists. To initiate study of the structure-function relationship during this process, we first ectopically expressed the wild-type delta OR and a C-terminally truncated mutant in CHO cells to investigate the necessity of its C-terminus. The binding potency of both the wild-type and… CONTINUE READING