The carboxyl terminus controls ligand-dependent activation of VEGFR-2 and its signaling.

Abstract

Vascular endothelial growth factor receptor-2 (VEGFR-2/FLK-1) is a receptor tyrosine kinase whose activation stimulates angiogenesis. We recently generated a chimeric VEGFR-2 in which the extracellular domain of VEGFR-2 was replaced with the extracellular domain of human colony stimulating factor-1 receptor and expressed in endothelial cells. To study the… (More)

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Cite this paper

@article{Meyer2004TheCT, title={The carboxyl terminus controls ligand-dependent activation of VEGFR-2 and its signaling.}, author={Rosana D. Meyer and Amrik Singh and Nader Rahimi}, journal={The Journal of biological chemistry}, year={2004}, volume={279 1}, pages={735-42} }