The carboxyl-terminal region of factor IX is essential for its secretion.

@article{Kurachi1997TheCR,
  title={The carboxyl-terminal region of factor IX is essential for its secretion.},
  author={Sumiko Kurachi and Dennis Peter Pantazatos and Kotoku Kurachi},
  journal={Biochemistry},
  year={1997},
  volume={36 14},
  pages={
          4337-44
        }
}
The carboxyl-terminal region of factor IX (residues 403-415) contains several natural mutations which result in mild to severe forms of hemophilia B. A battery of factor IX minigene expression vectors carrying various mutations in the C-terminal region were constructed and studied by transient expression assay using HepG2 cells. Mutations included in this study are Y404P, I408N, T412N, T412S, T415G, T415S, T415L, and T415R as well as five selected naturally occurring mutations in the region… CONTINUE READING
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