The carboxyl-terminal fragment of pro-HB-EGF reverses Bcl6-mediated gene repression.

@article{Kinugasa2007TheCF,
  title={The carboxyl-terminal fragment of pro-HB-EGF reverses Bcl6-mediated gene repression.},
  author={Yumi Kinugasa and Miki Hieda and Masatsugu Hori and Shigeki Higashiyama},
  journal={The Journal of biological chemistry},
  year={2007},
  volume={282 20},
  pages={14797-806}
}
Heparin-binding epidermal growth factor-like growth factor (HB-EGF), a member of the EGF family, is synthesized as a type I transmembrane precursor (pro-HB-EGF). Ectodomain shedding of pro-HB-EGF yields an amino-terminal soluble ligand of EGF receptor (HB-EGF) and a carboxyl-terminal fragment (HB-EGF-CTF) consisting of the transmembrane and cytoplasmic… CONTINUE READING