The carboxyl-terminal ahnak domain induces actin bundling and stabilizes muscle contraction.

@article{Haase2004TheCA,
  title={The carboxyl-terminal ahnak domain induces actin bundling and stabilizes muscle contraction.},
  author={Hannelore Haase and Ines Pagel and Yana N Khalina and Udo Zacharzowsky and Veronika Person and Gudrun Lutsch and Daria Petzhold and Monika Kott and Jutta Schaper and Ingo Morano},
  journal={FASEB journal : official publication of the Federation of American Societies for Experimental Biology},
  year={2004},
  volume={18 7},
  pages={839-41}
}
Ahnak, a 700 kDa protein, is expressed in a variety of cells and has been implicated in different cell-type-specific functions. In the human heart, we observed an endogenous carboxyl-terminal 72 kDa ahnak fragment that copurified with myofibrillar proteins. Immunocytochemistry combined with confocal microscopy localized this fragment to the intercalated discs and close to the Z-line of cardiomyocytes. No endogenous myofibrillar ahnak fragment was observed in the skeletal muscle. We elucidated… CONTINUE READING