The carboxy terminus of pp60c-src is a regulatory domain and is involved in complex formation with the middle-T antigen of polyomavirus.

@article{Cheng1988TheCT,
  title={The carboxy terminus of pp60c-src is a regulatory domain and is involved in complex formation with the middle-T antigen of polyomavirus.},
  author={Seng H. Cheng and Helen Piwnica-Worms and Riback Harvey and Thomas M Roberts and Alan W. Smith},
  journal={Molecular and cellular biology},
  year={1988},
  volume={8 4},
  pages={1736-47}
}
A large number of mutations were introduced into the carboxy-terminal domain of pp60c-src. The level of phosphorylation on Tyr-416 and Tyr-527, the transforming activity (as measured by focus formation on NIH 3T3 cells), kinase activity, and the ability of the mutant pp60c-src to associate with the middle-T antigen of polyomavirus were examined. The results… CONTINUE READING