The carboxy terminus of Tub4p is required for gamma-tubulin function in budding yeast.

@article{Vogel2000TheCT,
  title={The carboxy terminus of Tub4p is required for gamma-tubulin function in budding yeast.},
  author={Jacalyn Vogel and Michael Snyder},
  journal={Journal of cell science},
  year={2000},
  volume={113 Pt 21},
  pages={
          3871-82
        }
}
The role of gamma-tubulin in microtubule nucleation is well established, however, its function in other aspects of microtubule organization is unknown. The carboxy termini of alpha/beta-tubulins influence the assembly and stability of microtubules. We investigated the role of the carboxy terminus of yeast gamma-tubulin (Tub4p) in microtubule organization. This region consists of a conserved domain (DSYLD), and acidic tail. Cells expressing truncations lacking the DSYLD domain, tail or both… CONTINUE READING

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