The carboxy-terminal hydrophobic domain of TIG3, a class II tumor suppressor protein, is required for appropriate cellular localization and optimal biological activity.

@article{Deucher2000TheCH,
  title={The carboxy-terminal hydrophobic domain of TIG3, a class II tumor suppressor protein, is required for appropriate cellular localization and optimal biological activity.},
  author={Anne Deucher and Sunil Nagpal and Roshantha A. S. Chandraratna and D Di Sepio and N A Robinson and Shervin R. Dashti and Richard L Eckert},
  journal={International journal of oncology},
  year={2000},
  volume={17 6},
  pages={1195-203}
}
TIG3 is a recently discovered class II tumor suppressor protein, originally isolated from retinoid-treated cultured epidermal keratinocytes, that suppresses the proliferation of a variety of epithelial cell types. In the present study, we examine the ability of this protein to reduce CHO, T47D and HaCaT cell proliferation, and the role of the carboxy-terminal hydrophobic domain in this regulation. Vector-mediated expression of the full length TIG3 protein, TIG31-164, results in a 50-70… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 21 extracted citations

All trans retinoic acid and cancer.

Immunopharmacology and immunotoxicology • 2011
View 8 Excerpts
Highly Influenced

Similar Papers

Loading similar papers…