The carboxy-terminal domains of erbB-2 and epidermal growth factor receptor exert different regulatory effects on intrinsic receptor tyrosine kinase function and transforming activity.

@article{Fiore1990TheCD,
  title={The carboxy-terminal domains of erbB-2 and epidermal growth factor receptor exert different regulatory effects on intrinsic receptor tyrosine kinase function and transforming activity.},
  author={Pier Paolo Di Fiore and Oreste Segatto and Fulvio Lonardo and Francesca Fazioli and Jacalyn H. Pierce and Stuart A. Aaronson},
  journal={Molecular and cellular biology},
  year={1990},
  volume={10 6},
  pages={2749-56}
}
The erbB-2 gene product, gp185erbB-2, displays a potent transforming effect when overexpressed in NIH 3T3 cells. In addition, it possesses constitutively high levels of tyrosine kinase activity in the absence of exogenously added ligand. In this study, we demonstrate that its carboxy-terminal domain exerts an enhancing effect on erbB-2 kinase and transforming activities. A premature termination mutant of the erbB-2 protein, lacking the entire carboxy-terminal domain (erbB-2 delta 1050), showed… CONTINUE READING

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