The capsular polysaccharide of Bacteroides fragilis as a virulence factor: comparison of the pathogenic potential of encapsulated and unencapsulated strains.

@article{Onderdonk1977TheCP,
  title={The capsular polysaccharide of Bacteroides fragilis as a virulence factor: comparison of the pathogenic potential of encapsulated and unencapsulated strains.},
  author={Andrew B. Onderdonk and Dennis L Kasper and Ronald L Cisneros and John G. Bartlett},
  journal={The Journal of infectious diseases},
  year={1977},
  volume={136 1},
  pages={82-9}
}
The pathogenic potentials of encapsulated and unencapsulated strains of Bacteroides fragilis were compared by use of a rat model of intraabdominal sepsis. Implantation of encapsulated B. fragilis alone resulted in abscesses in most recipients, whereas unencapsulated strains seldom produced this effect unless they were combined with another organism. Implants of heat-killed, encapsulated B. fragilis also resulted in abscess formation. Subsequent experiments suggested that the abscess… CONTINUE READING