The capability of catabolic utilization of N-acetylneuraminic acid, a sialic acid, is essential for Vibrio vulnificus pathogenesis.

@article{Jeong2009TheCO,
  title={The capability of catabolic utilization of N-acetylneuraminic acid, a sialic acid, is essential for Vibrio vulnificus pathogenesis.},
  author={Hee Gon Jeong and Man Hwan Oh and Byoung Sik Kim and Min Young Lee and Ho Jae Han and Sang Ho Choi},
  journal={Infection and immunity},
  year={2009},
  volume={77 8},
  pages={3209-17}
}
N-acetylneuraminic acid (Neu5Ac, sialic acid) could provide a good substrate for enteropathogenic bacteria in the intestine, when the bacteria invade and colonize in human gut. In order to analyze the role of Neu5Ac catabolism in Vibrio vulnificus pathogenesis, a mutant with disruption of the nanA gene encoding Neu5Ac lyase was constructed by allelic exchanges. The nanA mutant was not able to utilize Neu5Ac as a sole carbon source and revealed an altered colony morphotype with reduced opacity… CONTINUE READING

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