The cap-translation inhibitor 4EGI-1 induces apoptosis in multiple myeloma through Noxa induction

@inproceedings{Descamps2012TheCI,
  title={The cap-translation inhibitor 4EGI-1 induces apoptosis in multiple myeloma through Noxa induction},
  author={G{\'e}raldine Descamps and Patricia Gomez-Bougie and J{\'e}r{\^o}me Tamburini and Anna Gr{\'e}en and Didier Bouscary and Sophie Ma{\"i}ga and Philippe Moreau and Stephen Le Gouill and Catherine Pellat-Deceunynck and Martine Amiot},
  booktitle={British Journal of Cancer},
  year={2012}
}
Background:Cancer cells are frequently addicted to deregulated oncogenic protein translation. The small molecule 4EG-I selectively inhibits the cap-dependent translation of mRNAs. As multiple myeloma is an incurable disease that requires new therapeutic approaches, we investigated whether targeting the translation initiation pathway could be a target for myeloma therapy.Methods:Six myeloma cell lines and primary samples were included in this study. The 4EGI-1 effect was determined by AnnexinV… CONTINUE READING