The canonical Wnt signaling pathway in autism.

  title={The canonical Wnt signaling pathway in autism.},
  author={Yinghua Zhang and Xiangshan Yuan and Zhongping Wang and Ruixi Li},
  journal={CNS & neurological disorders drug targets},
  volume={13 5},
Mounting attention is being focused on the canonical Wnt signaling pathway which has been implicated in the pathogenesis of autism in some our and other recent studies. The canonical Wnt pathway is involved in cell proliferation, differentiation and migration, especially during nervous system development. Given its various functions, dysfunction of the canonical Wnt pathway may exert adverse effects on neurodevelopment and therefore leads to the pathogenesis of autism. Here, we review human and… CONTINUE READING

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