The canonical Notch/RBP-J signaling pathway controls the balance of cell lineages in mammary epithelium during pregnancy.

@article{Buono2006TheCN,
  title={The canonical Notch/RBP-J signaling pathway controls the balance of cell lineages in mammary epithelium during pregnancy.},
  author={Krista D Buono and Gertraud W. Robinson and Cyril Martin and Shaolin Shi and Pamela Stanley and Kenji Tanigaki and T. Honjo and Lothar Hennighausen},
  journal={Developmental biology},
  year={2006},
  volume={293 2},
  pages={565-80}
}
Mammary alveoli are composed of luminal (secretory) and basal (myoepithelial) cells, which are descendants of a common stem cell. This study addressed the role of RBP-J-dependent Notch signaling in the formation, maintenance and cellular composition of alveoli during pregnancy. For this purpose, the genes encoding RBP-J, the shared transcriptional mediator of Notch receptors, and Pofut1, a fucosyltransferase required for the activity of Notch receptors, were deleted in mammary progenitor cells… CONTINUE READING