The cannabinoids as potential antiepileptics.

  title={The cannabinoids as potential antiepileptics.},
  author={Ralph Karler and Stuart A. Turkanis},
  journal={Journal of clinical pharmacology},
  volume={21 S1},
Comparative studies of the anticonvulsant properties of the cannabinoids and prototype antiepileptic drugs in numerous animal seizure models demonstrate that (1) as an anticonvulsant, cannabidiol (CBD), in contrast to delta 9-tetrahydrocannabinol (THC), is relatively selective in terms of both central nervous system (CNS), depressant and excitatory properties; (2) the potency of cannabidiol, unlike that of phenytoin and phenobarbital, varies greatly with the species; (3) the large potency… CONTINUE READING
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