The cannabinoid system and immune modulation

@article{Klein2003TheCS,
  title={The cannabinoid system and immune modulation},
  author={Thomas W. Klein and Catherine A. Newton and Kellie Larsen and Lily Lu and Izabella Perkins and Liang Nong and Herman Friedman},
  journal={Journal of Leukocyte Biology},
  year={2003},
  volume={74}
}
Studies on the effects of marijuana smoking have evolved into the discovery and description of the endocannabinoid system. To date, this system is composed of two receptors, CB1 and CB2, and endogenous ligands including anandamide, 2‐arachidonoyl glycerol, and others. CB1 receptors and ligands are found in the brain as well as immune and other peripheral tissues. Conversely, CB2 receptors and ligands are found primarily in the periphery, especially in immune cells. Cannabinoid receptors are G… 

Endocannabinoids and immune regulation.

Cannabinoids and the immune system: an overview.

The emerging role of the endocannabinoid system in cardiovascular disease

The therapeutic potential of the modulation of the ECS by selective agonists/antagonists in various cardiovascular disorders associated with inflammation and tissue injury, ranging from myocardial infarction and heart failure to atherosclerosis and cardiometabolic disorders is discussed.

The Interplay between the Immune and the Endocannabinoid Systems in Cancer

The recent characterization of the human cannabinoid receptor CB2-Gi signaling complex will likely aid to design potent and specific CB2/CB1 ligands with therapeutic potential in cancer.

The emerging role of the endocannabinoid system in endocrine regulation and energy balance.

The ability of the endocannabinoid system to control appetite, food intake, and energy balance has recently received great attention, particularly in the light of the different modes of action underlying these functions.

Therapeutic potential of cannabinoid-based drugs.

  • T. KleinC. Newton
  • Biology, Medicine
    Advances in experimental medicine and biology
  • 2007
Preclinical data with cannabinoid-based drugs suggest efficacy in other inflammatory diseases such as inflammatory bowel disease, Alzheimer's disease, atherosclerosis, and osteoporosis.

Cannabinoid-Induced Immune Suppression and Modulation of Antigen-Presenting Cells

Current information on cannabinoid ligand and receptor biology, mechanisms involved in immune suppression by cannabinoids with emphasis on antigen-presenting cells, and preclinical and clinical models analyzing the therapeutic potential of cannabinoid-based drugs are reviewed.

Effects on Immune Cells of a New 1,8-Naphthyridin-2-One Derivative and Its Analogues as Selective CB2 Agonists: Implications in Multiple Sclerosis

Assessment of the potential immune-modulatory effects of novel compounds in activated lymphocytes isolated from MS patients with respect to healthy controls suggests potential application of these drugs in neuro-inflammation, supporting further investigations of the effects of compounds in the therapy of MS.

Interaction between Cannabinoid System and Toll-Like Receptors Controls Inflammation

  • K. McCoy
  • Biology
    Mediators of inflammation
  • 2016
The endocannabinoid system and Toll-like receptor family and the interaction between them are discussed and new potential molecular targets in developing therapeutic strategies for chronic inflammatory diseases are identified.

The Endocannabinoid System as an Emerging Target of Pharmacotherapy

A comprehensive overview on the current state of knowledge of the endocannabinoid system as a target of pharmacotherapy is provided.
...

References

SHOWING 1-10 OF 141 REFERENCES

Cannabinoids and the immune system.

It is likely that the cannabinoid system, along with other neuroimmune systems, has a subtle but significant role in the regulation of immunity and that this role can eventually be exploited in the management of human disease.

The cannabinoid system and cytokine network.

Enough evidence exists to suggest that the cannabinoid system significantly impacts the functioning of the cytokine network, and this association may provide clues to the mechanisms of certain immune diseases and form the basis for new immunotherapies.

Cannabinoid-receptor expression in human leukocytes.

The demonstration of cannabinoid-receptor expression at both mRNA and protein levels on human leukocytes provides a molecular basis for cannabinoid action on these cells.

Cannabinoid receptors and the regulation of immune response.

Molecular characterization of a peripheral receptor for cannabinoids

The cloning of a receptor for cannabinoids is reported that is not expressed in the brain but rather in macrophages in the marginal zone of spleen, which helps clarify the non-psychoactive effects of cannabinoids.

Marijuana, immunity and infection

Structure of a cannabinoid receptor and functional expression of the cloned cDNA

The cloning and expression of a complementary DNA that encodes a G protein-coupled receptor that is involved in cannabinoid-induced CNS effects (including alterations in mood and cognition) experienced by users of marijuana are suggested.

Expression of central and peripheral cannabinoid receptors in human immune tissues and leukocyte subpopulations.

The results suggest that CB1 and CB2 can be considered as tissue-selective antigens of the central nervous system and immune system, respectively, and cannabinoids may exert specific receptor-mediated actions on the immune system through the CB2 receptor.

Expression of cannabinoid receptor mRNA in murine and human leukocytes.

Results suggest cannabinoid receptors have biological relevance in lymphoid cells because: receptor mRNA is detected in some resting immune cells but not others and the mRNA increases during cell activation.
...