The cannabinoid receptor antagonist SR-141716 does not readily antagonize open-field effects induced by the cannabinoid receptor agonist (R)-methanandamide in rats.

@article{Jrbe2003TheCR,
  title={The cannabinoid receptor antagonist SR-141716 does not readily antagonize open-field effects induced by the cannabinoid receptor agonist (R)-methanandamide in rats.},
  author={Torbj{\"o}rn U. C. J{\"a}rbe and Nicholas V Dipatrizio and Chen Li and Alexandros Makriyannis},
  journal={Pharmacology, biochemistry, and behavior},
  year={2003},
  volume={75 4},
  pages={809-21}
}
This study examined the effects of the cannabinoid CB(1) receptor agonist (R)-methanandamide and the CB(1) receptor antagonist SR-141716 on open-field behaviors in rats. Animals were examined after administration of (R)-methanandamide (dose range 10 to 30 mg/kg) plus vehicle, and the two drugs in combination; the dose range of SR-141716 was 0.3 to 5.6 mg/kg. Injections were given intraperitoneally 20 min prior to initial testing. Additional exposures to the open-field arena occurred for the… CONTINUE READING