The cannabinoid receptor: biochemical, anatomical and behavioral characterization

@article{Howlett1990TheCR,
  title={The cannabinoid receptor: biochemical, anatomical and behavioral characterization},
  author={Allyn C. Howlett and Michelle Bidaut-Russell and William A. Devane and Lawrence S. Melvin and M.Ross Johnson and Miles Herkenham},
  journal={Trends in Neurosciences},
  year={1990},
  volume={13},
  pages={420-423}
}
The actions of the active principle of marihuana, delta 9-tetrahydrocannabinol, are mimicked by synthetic cannabinoid agonists showing high potency and enantio-selectivity in behavioral assays. These drugs have been used to characterize cannabinoid receptor binding, biochemistry and pharmacology, leading to a better understanding of the effects of cannabinoids in the CNS of humans and experimental animals. 
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References

SHOWING 1-10 OF 27 REFERENCES
Cannabinoid inhibition of adenylate cyclase: Relative activity of constituents and metabolites of marihuana
  • A. Howlett
  • Chemistry, Medicine
  • Neuropharmacology
  • 1987
TLDR
Compared to the pharmacology of cannabinoids reported for psychological effects in humans and behavioral effects in a variety of animal models, delta 8Tetrahydrocannabinol was less active, and cannabinol was only partially active. Expand
Nonclassical cannabinoid analgetics inhibit adenylate cyclase: development of a cannabinoid receptor model.
TLDR
It is postulated that the receptor that is associated with the regulation of adenylate cyclase in vitro may be the same receptor as that mediating analgesia in vivo, and a conceptualization of the cannabinoid analgetic receptor is presented. Expand
Pharmacology and stereoselectivity of structurally novel cannabinoids in mice.
TLDR
The pharmacological effects of three stereoisomeric pairs of structurally novel cannabinoids were tested after i.v. administration in mice for depression of spontaneous activity and the production of hypothermia, antinociception and catalepsy to demonstrate the high degree of enantioselectivity and potency. Expand
Cellular effects of cannabinoids.
  • B. Martin
  • Chemistry, Medicine
  • Pharmacological reviews
  • 1986
TLDR
The many studies that have been included in this review suggest that cannabinoids have ubiquitous effects on biological systems and that low doses of delta 9-THC are capable of producing the psychoactivity that is unique to cannabinoids, whereas higher doses may produce effects that are both specific and nonspecific for cannabinoids. Expand
An Assessment of the Role of Opioid Receptors in the Response to Cannabimimetic Drugs
TLDR
The effectiveness of the cannabimimetic response does not correlate with the efficacy of the opioid response, and the interaction between desacetyllevonantradol and etorphine was neither synergistic nor additive at maximal concentrations, suggesting that these two drugs operate via the same effector mechanism. Expand
Determination and characterization of a cannabinoid receptor in rat brain.
TLDR
The criteria for a high affinity, stereoselective, pharmacologically distinct cannabinoid receptor in brain tissue have been fulfilled. Expand
Inhibition of naloxone-induced withdrawal in morphine dependent mice by 1-trans-delta9-tetrahydrocannabinol.
  • H. Bhargava
  • Chemistry, Medicine
  • European journal of pharmacology
  • 1976
TLDR
Delta9-THC or some of its derivatives may have potential use in narcotic detoxification and two other signs of morphine withdrawal were suppressed by deltapTHC. Expand
Delta 9-tetrahydrocannabinol increases arachidonic acid levels in guinea pig cerebral cortex slices.
TLDR
In brain, as in extra-neural cells in culture, cannabinoids increase unesterified AA levels; however, the relative potencies of the cannabinoids the authors examined in increasing AA levels do not correlate well with their in vivo psychoactive potencies. Expand
A Comparison of THC, Nantradol, Nabilone, and Morphine in the Chronic Spinal Dog
  • P. Gilbert
  • Medicine
  • Journal of clinical pharmacology
  • 1981
TLDR
The results suggest that THC, nantradol, and nabilone share some properties with morphine since they increased the latency of the skin twitch reflex and suppressed withdrawal abstinence. Expand
Catalepsy induced by intrastriatal injections of Δ9-THC and 11-OH-Δ9-THC in the rat
Intrastriatal injections of Δ9-THC and 1 l-hydroxy-Δ9-THC induced dose-dependent catalepsy in the rat, the parent compound being more potent than the metabolite. Catalepsy was not induced followingExpand
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