The cannabinoid antagonist SR144528 enhances the acute effect of WIN 55,212‐2 on gastrointestinal motility in the rat

@article{Abalo2010TheCA,
  title={The cannabinoid antagonist SR144528 enhances the acute effect of WIN 55,212‐2 on gastrointestinal motility in the rat},
  author={Raquel Abalo and Pablo Antonio Cabezos and Gema Vera and R. Fern{\'a}ndez‐pujol and M. I. Martı́n},
  journal={Neurogastroenterology \& Motility},
  year={2010},
  volume={22}
}
Background  In the absence of pathology, cannabinoid‐induced depression of gastrointestinal (GI) motility is thought to be mediated primarily by CB1 receptors, whereas the role of CB2 receptors is still unclear. The aim of this work was to radiographically analyze the acute effect of the mixed cannabinoid agonist WIN 55,212‐2 (WIN) on GI motor function in the rat, focusing on the involvement of CB1 and CB2 receptors. 
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Highly Influential Citations
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22 Citations

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The effect of intermittent treatment with the CB1/CB2 cannabinoid agonist WIN55,212‐2 (WIN) was studied in the rat and it was found that these effects might be modified upon repeated administration.
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The aims were to characterize the effects of the recently developed highly potent long‐acting megagonist AM841 on GI motor function and to determine its central effects in rats.
Cannabinoids may worsen gastric dysmotility induced by chronic cisplatin in the rat
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The aim was to analyze the effects of the non‐selective cannabinoid agonist WIN 55 212‐2 (WIN) on gastrointestinal (GI) dysmotility and other adverse effects induced by repeated cisplatin administration in the rat.
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The gastrointestinal (GI) pharmacology of CBs is reviewed, with special focus on motor function, as well as central and peripheral side effects may occur upon acute and chronic CB administration.
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Gut feelings about the endocannabinoid system
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Novel data highlight the multi‐faceted aspects of endocannabinoid function in the GI tract, support the feasibility of the future therapeutic exploitation of this signaling system for the treatment of GI disorders, and leave space for some intriguing new hypotheses on the role ofendocannabinoids in the gut.
Involvement of Cannabinoid Signaling in Vincristine-Induced Gastrointestinal Dysmotility in the Rat
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The fact that AM251, but not AM630, is capable of reducing the effect of vincristine suggests that, like in other experimental models of paralytic ileus, an increased cannabinoid tone develops and is at least partially responsible for the alterations induced by the antitumoral drug on gastrointestinal motor function.
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