The cannabinoid TRPA1 agonist cannabichromene inhibits nitric oxide production in macrophages and ameliorates murine colitis.

@article{Romano2013TheCT,
  title={The cannabinoid TRPA1 agonist cannabichromene inhibits nitric oxide production in macrophages and ameliorates murine colitis.},
  author={Barbara Romano and Francesca Borrelli and Ines Fasolino and Raffaele Capasso and Fabiana Piscitelli and Mg Cascio and Rg Pertwee and Diana Coppola and Lorenzo Vassallo and Pierangelo Orlando and Vincenzo Di Marzo and Aa Izzo},
  journal={British journal of pharmacology},
  year={2013},
  volume={169 1},
  pages={213-29}
}
BACKGROUND AND PURPOSE The non-psychotropic cannabinoid cannabichromene is known to activate the transient receptor potential ankyrin-type1 (TRPA1) and to inhibit endocannabinoid inactivation, both of which are involved in inflammatory processes. We examined here the effects of this phytocannabinoid on peritoneal macrophages and its efficacy in an experimental model of colitis. EXPERIMENTAL APPROACH Murine peritoneal macrophages were activated in vitro by LPS. Nitrite levels were measured… CONTINUE READING
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