The cannabinoid CB1 receptor antagonist AM251 does not modify methamphetamine reinstatement of responding.

@article{Boctor2007TheCC,
  title={The cannabinoid CB1 receptor antagonist AM251 does not modify methamphetamine reinstatement of responding.},
  author={Sherin Y. Boctor and J-M. Martinez and Wouter Koek and Charles P France},
  journal={European journal of pharmacology},
  year={2007},
  volume={571 1},
  pages={
          39-43
        }
}
Cannabinoid CB(1) receptor antagonists can decrease methamphetamine self-administration. This study examined whether the CB(1) receptor antagonist AM251 [N-(piperidin-1-yl)-5-(4-indophonyl)-1-(2,4-dichlorophenyl)-4-methyl-1H-pyrazole-3-carboxamide] modifies reinstatement in rats that previously self-administered methamphetamine. Rats (n=10) self-administered methamphetamine (0.1 mg/kg/infusion) under a fixed ratio 2 schedule. Non-contingent methamphetamine (0.01-1.78 mg/kg, i.v.) yielded… CONTINUE READING
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