The canine spleen in oxygen transport: gas exchange and hemodynamic responses to splenectomy.

@article{Hsia2007TheCS,
  title={The canine spleen in oxygen transport: gas exchange and hemodynamic responses to splenectomy.},
  author={Connie C W Hsia and Robert L. Johnson and D. Merrill Dane and Eugene Y. Wu and Aaron S. Estrera and Harrieth E. Wagner and Peter D. Wagner},
  journal={Journal of applied physiology},
  year={2007},
  volume={103 5},
  pages={1496-505}
}
In athletic animals the spleen induces acute polycythemia by dynamic contraction that releases red blood cells into the circulation in response to increased O(2) demand and metabolic stress; when energy demand is relieved, the polycythemia is rapidly reversed by splenic relaxation. We have shown in adult foxhounds that splenectomy eliminates exercise… CONTINUE READING