The candidate tumour suppressor p33ING1cooperates with p53 in cell growth control

@article{Garkavtsev1998TheCT,
  title={The candidate tumour suppressor p33ING1cooperates with p53 in cell growth control},
  author={Igor V. Garkavtsev and Irina A. Grigorian and Valeria s. Ossovskaya and Mikhail V. Chernov and Peter M. Chumakov and Andrei V Gudkov},
  journal={Nature},
  year={1998},
  volume={391},
  pages={295-298}
}
The candidate tumour-suppressor gene ING1 has been identified by using the genetic suppressor element (GSE) methodology. ING1 encodes a nuclear protein, p33ING1, overexpression of which inhibits growth of different cell lines. The properties of p33ING1suggest its involvement in the negative regulation of cell proliferation and in the control of cellular ageing, anchorage dependence and apoptosis. These cellular functions depend largely on the activity of p53, a tumour-suppressor gene that… 
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TLDR
It is found that there was no difference in ING1 mRNA and protein levels between p53+/+ and p53–/– murine organs, and it is concluded that the expression of ING 1 is independent of p53 status.
Growth Inhibition by the Tumor Suppressor p33ING1 in Immortalized and Primary Cells: Involvement of Two Silencing Domains and Effect of Ras
TLDR
It is shown that p33ING1 is a potent transcriptional silencer in various cell types, and both silencing domains of ING1 are involved in cell cycle control, as measured by inhibition of colony formation of immortalized cells and by thymidine incorporation of primary human diploid fibroblasts (HDF).
The tumor suppressor candidate p33(ING1) mediates repair of UV-damaged DNA.
TLDR
It is found that overexpression of p33(ING1) enhances repair of UV-damaged DNA and that p53 is required for the repair process, and binding between ING1 and GADD45 has been detected, suggesting that p 33(ING 1) cooperates with p53 in nucleotide excision repair and that Gadd45 may be one of its components.
Regulation of p53 downstream genes.
  • W. El-Deiry
  • Biology, Medicine
    Seminars in cancer biology
  • 1998
TLDR
The p53 tumor suppressor is the most commonly mutated gene in human cancer and its activation of expression of a number of target genes including p21WAFI, GADD45, 14-3-3 sigma, bax, Fas/APO1, KILLER/DR5, PIG3, Tsp1, IGF-BP3 and others are reviewed.
Deletion of p37Ing1 in mice reveals a p53-independent role for Ing1 in the suppression of cell proliferation, apoptosis, and tumorigenesis.
TLDR
The results indicate that p53 does not require p37(Ing1) to negatively regulate cell growth and offers genetic proof that Ing1 suppressescell growth and tumorigenesis, and reveal that p37 (Ing1), a plant homeodomain protein that interacts with the p53 tumor suppressor protein, can negatively regulate Cell growth and apoptosis in a p53-independent manner.
Reduced expression of p33ING1 and the relationship with p53 expression in human gastric cancer
TLDR
The findings are interpreted to mean that p33 ING1 may function as a tumor suppressor in gastric carcinogenesis, even though the gene is preserved in the majority of gastrointestinal carcinomas.
Generation of p53 Suppressor Peptide From the Fragment of p53 Protein
TLDR
The rationale and methodological basis for efficient generation of biologically active peptides with therapeutic potential from GSEs isolated from a library of randomly fragmented p53 cDNA is provided.
Regulation of p53 by ING family members in suppression of tumor initiation and progression
TLDR
This review summarizes the current understanding of the mutual interactions and cooperation between different members of ING family with p53 pathway and implications of this cooperation in the suppression of cancer initiation and progression.
The cellular response to p53: the decision between life and death
The p53 tumor suppressor protein plays a crucial role in regulating cell growth following exposure to various stress stimuli. p53 induces either growth arrest, which prevents the replication of
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