The candidate tumor suppressor gene ZAC is involved in keratinocyte differentiation and its expression is lost in basal cell carcinomas.

@article{Basyuk2005TheCT,
  title={The candidate tumor suppressor gene ZAC is involved in keratinocyte differentiation and its expression is lost in basal cell carcinomas.},
  author={Eugenia I. Basyuk and Vincent Coulon and Anne Le Digarcher and Marjorie Coisy-Quivy and Jean-Pierre Mol{\`e}s and Alberto Gandarillas and Laurent Journot},
  journal={Molecular cancer research : MCR},
  year={2005},
  volume={3 9},
  pages={483-92}
}
ZAC is a zinc finger transcription factor that induces apoptosis and cell cycle arrest in various cell lines. The corresponding gene is maternally imprinted and localized on chromosome 6q24-q25, a region harboring an unidentified tumor suppressor gene for a variety of solid neoplasms. ZAC expression is lost or down-regulated in some breast, ovary, and pituitary tumors and in an in vitro model of ovary epithelial cell transformation. In the present study, we examined ZAC expression in normal… CONTINUE READING

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