The candidate tumor suppressor SASH1 interacts with the actin cytoskeleton and stimulates cell-matrix adhesion.

@article{Martini2011TheCT,
  title={The candidate tumor suppressor SASH1 interacts with the actin cytoskeleton and stimulates cell-matrix adhesion.},
  author={Melanie Martini and Alexandra Gnann and Daniela Scheikl and Bernhard Holzmann and K. P. Janssen},
  journal={The international journal of biochemistry & cell biology},
  year={2011},
  volume={43 11},
  pages={1630-40}
}
SASH1, a member of the SLY-family of signal adapter proteins, is a candidate tumor suppressor in breast and colon cancer. Reduced expression of SASH1 is correlated with aggressive tumor growth, metastasis formation, and inferior prognosis. However, the biological role of SASH1 remains largely unknown. To unravel the function of SASH1, we have analyzed the intracellular localization of endogenous SASH1, and have generated structural SASH1 mutants. SASH1 localized to the nucleus as well as to the… CONTINUE READING