Corpus ID: 429192

The candidate tumor suppressor ING1b can stabilize p53 by disrupting the regulation of p53 by MDM2.

@article{Leung2002TheCT,
  title={The candidate tumor suppressor ING1b can stabilize p53 by disrupting the regulation of p53 by MDM2.},
  author={K. Leung and Lai See Po and Fan Cheung Tsang and W. Y. Siu and A. Lau and Horace T. B. Ho and R. Poon},
  journal={Cancer research},
  year={2002},
  volume={62 17},
  pages={
          4890-3
        }
}
ING1b is a candidate tumor suppressor that can stimulate the transcriptional activity of p53 and inhibit cell proliferation. The molecular basis of how ING1b activates p53 function remains unclear. Here we show that ING1b could stimulate the activity of p53 by increasing the level and stability of the p53 protein. The stabilization and activation of p53 by ING1b could be reversed by MDM2 in a dose-dependent manner. Conversely, ING1b could reverse the inhibition and degradation of p53 caused by… Expand
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