The candidate oncoprotein Bcl-3 is an antagonist of p50/NF-kappa B-mediated inhibition.

@article{Franzoso1992TheCO,
  title={The candidate oncoprotein Bcl-3 is an antagonist of p50/NF-kappa B-mediated inhibition.},
  author={Guido Franzoso and Vincent Bours and S Park and M Tomita-Yamaguchi and Kathleen Kelly and Ulrich K Siebenlist},
  journal={Nature},
  year={1992},
  volume={359 6393},
  pages={339-42}
}
The candidate oncogene bcl-3 was discovered as a translocation into the immunoglobulin alpha-locus in some cases of B-cell chronic lymphocytic leukaemias. The protein Bcl-3 contains seven so-called ankyrin repeats. Similar repeat motifs are found in a number of diverse regulatory proteins but the motifs of Bcl-3 are most closely related to those found in I kappa B proteins in which the ankyrin repeat domain is thought to be directly involved in inhibition of NF-kappa B activity. No biological… CONTINUE READING

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