The candidate MAP kinase phosphorylation substrate DPL-1 (DP) promotes expression of the MAP kinase phosphatase LIP-1 in C. elegans germ cells.

@article{Lin2008TheCM,
  title={The candidate MAP kinase phosphorylation substrate DPL-1 (DP) promotes expression of the MAP kinase phosphatase LIP-1 in C. elegans germ cells.},
  author={Baiqing Lin and Valerie Reinke},
  journal={Developmental biology},
  year={2008},
  volume={316 1},
  pages={50-61}
}
The highly-conserved, commonly used MAP kinase signaling cascade plays multiple integral roles in germline development in Caenorhabditis elegans. Using a functional proteomic approach, we found that the transcription factor DPL-1, a component of the LIN-35(Rb)/EFL-1(E2F)/DPL-1(DP) pathway, is a candidate phosphorylation substrate of MAP kinase. Moreover, dpl-1 genetically interacts with mpk-1(MAP kinase) to control chromosome morphology in pachytene of meiosis I, as does lin-35. However, EFL-1… CONTINUE READING