The cancer-testis antigen BORIS phenocopies the tumor suppressor CTCF in normal and neoplastic cells.

@article{Tiffen2013TheCA,
  title={The cancer-testis antigen BORIS phenocopies the tumor suppressor CTCF in normal and neoplastic cells.},
  author={Jessamy C. Tiffen and Charles G. Bailey and Amy D. Marshall and Cynthia Metierre and Yue Feng and Qian Wang and Sarah Lucie Watson and Jeff Holst and John E J Rasko},
  journal={International journal of cancer},
  year={2013},
  volume={133 7},
  pages={1603-13}
}
BORIS and CTCF are paralogous, multivalent 11-zinc finger transcription factors that play important roles in organizing higher-order chromatin architecture. BORIS is a cancer-testis antigen with a poorly defined function in cancer, although it has been hypothesized to exhibit oncogenic properties. CTCF, however, has been postulated as a candidate tumor suppressor. We collated the genetic lesions in BORIS and CTCF from multiple cancers identified using high-throughput genomics. In BORIS… CONTINUE READING

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