The cancer stem-cell signaling network and resistance to therapy.

  title={The cancer stem-cell signaling network and resistance to therapy.},
  author={Amancio Carnero and Yoelsis Garcia-Mayea and Cristina Mir and J Lorente and Isabel Teresa Rubio and Matilde E LLeonart},
  journal={Cancer treatment reviews},
The study of cancer stem cells (CSCs) has shown that tumors are driven by a subpopulation of self-renewing CSCs that retain the capacity to engender the various differentiated cell populations that form tumors. The characterization of CSCs has indicated that CSCs are remarkably resistant to conventional radio- and chemo-therapy. Clinically, the remaining populations of CSC are responsible for metastasis and recurrence in patients with cancer, which can lead to the disease becoming chronic and… CONTINUE READING
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