The cancer stem cell model: B cell acute lymphoblastic leukaemia breaks the mould

The cancer stem cell (CSC) hypothesis postulates that tumours are arranged in a developmental hierarchy reflecting heterogeneity on the cellular level. Within a given tumour, only a subset of cells have the capacity to self-renew, give rise to more differentiated progeny and maintain the tumour long-term (Nguyen et al, 2012). The model implies that cancer… CONTINUE READING