The cancer preventive peptide lunasin from wheat inhibits core histone acetylation.

@article{Jeong2007TheCP,
  title={The cancer preventive peptide lunasin from wheat inhibits core histone acetylation.},
  author={Hyung Jin Jeong and Jin Boo Jeong and Dae Seop Kim and Jae Ho Park and Jung Bok Lee and D K Kweon and Gyu Young Chung and Eul Won Seo and Ben O. de Lumen},
  journal={Cancer letters},
  year={2007},
  volume={255 1},
  pages={42-8}
}
Lunasin is a unique 43-amino acid cancer preventive peptide initially reported in soybean and barley and has been shown to be chemopreventive in mammalian cells and in a skin cancer mouse model against oncogenes and chemical carcinogens. We report here the core histone H3- and H-acetylation inhibitory properties of lunasin from wheat, a new source of the peptide and from the livers of rats fed with lunasin-enriched wheat (LEW) to measure bioavailability. A non-radioactive histone acetyl… CONTINUE READING

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